As such, finding similar stretches of genes is not novel, unlikely, or particularly surprising. The authors declare no conflict of interest. Brighter days are ahead and a vaccine is coming! Heres why: Lyons-Weiler J. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. In part I, we focused on the big picture. On the figure, the two lines (comparing vaccinated and unvaccinated patient data) are almost in the same place for the first four or five days of illness, but then they separate, and the vaccinated group more quickly requires higher numbers of PCR cycles to detect viral RNA, meaning there was less virus in those samples. Click here:\rhttps://www.drbeen.com/yt-special-p/\r\rWant to support this work? But studies are showing that is not the case. followers 129 videos. DNA, which makes up our genetic code, is larger, double stranded and very long. Magnus Rasmussen Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage :\rBuy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed\rBecome my patron: https://www.patreon.com/mobeensyed?fan_landing=true\rPayPal: https://paypal.me/mobeensyed?locale.x=en_US\r\r#drbeen #koolbeens #COVID\r\rDisclaimer:\rThis video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. 2022 Feb 28;194(8):E297-E305. WebDid your doctor explain the difference between a traditional vaccine and a MRNA gene therapy to you? Imaging findings included inflammation, beading, stricturing, and dilation of the biliary tree. Suggested accounts. Available online: Mulligan M.J., Lyke K.E., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Raabe V., Bailey R., Swanson K.A., et al. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. Philadelphia, PA 19104, Know My Rights About Surprise Medical Bills. Ricke DO. The CDC says that the COVID-19 vaccines do not change or interact with your DNA in any way, claiming that all of the ingredients in both mRNA and viral vector COVID-19 vaccines (administered in the United States) are discarded from the body once antibodies are produced. Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study. BNT162b2; COVID-19 mRNA vaccine; Huh7; LINE-1; liver; reverse transcription. (. WebPfizer Vaccine Becomes DNA in Liver Cells. The product has been, During the foetal stage, a number of so-called cell programs run that are vital to the development of the foetus. Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. Fax: +46 (0)46 222 47 20, Invoice address: Box 188, 221 00 Lund That is why it is impossible to alter your DNA with mRNA vaccines. 2021 Feb 24;12:640093. N. Engl. The research was conducted at Lund University. Epub 2022 Feb 3. Sudden deaths of Canadian Dr. Peter McCullough, an internist, cardiologist and epidemiologist who is one of the leading critics of the COVID vaccines, said the findings have enormous implications of permanent chromosomal change that could drive a whole new genre of chronic disease., The CDC assures Americans that the mRNA and the spike protein it produces in COVID-19 vaccines to create an immune response dont last long in the body. On its website, the agency states: Our cells break down mRNA and get rid of it within a few days after vaccination. government site. Additionally, the mRNA vaccine does in fact travel to the liver and other locations such as ovaries. N. Engl. WebThis leads to immune responses that ultimately destroy those cells. YDM: This study does not investigate whether the Pfizer vaccine alters our genome. Tozinameran (BNT162b2) Vaccine: The Journey from Preclinical Research to Clinical Trials and Authorization. Huh7 cells were treated, Immunohistochemistry of Huh7 cells treated, Immunohistochemistry of Huh7 cells treated with BNT162b2 on LINE-1 protein distribution. Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. :\rBuy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed\rBecome my patron: https://www.patreon.com/mobeensyed?fan_landing=true\rPayPal: https://paypal.me/mobeensyed?locale.x=en_US\r\r#drbeen #koolbeens #COVID\r\rChapters00:00 introduction00:45 Link to the summary01:00 Review of the reference material02:19 Cell preparation for the vaccine03:35 Vaccine addition to the cells06:00 RT-PCR for find RNA and then DNA13:39 Imaging of the cells and the LINE-1 protein, ORF-1 protein, and the DNA18:27 Measuring the volume of proteins in the cytosol and the nucleus22:35 DNA purification and verification28:41 Results28:42 LNP enters the liver cells efficiently29:33 LINE-1 gene is expressed30:46 ORF-1 found in cytosol and the nucleus36:01 DNA from the vaccine found in the cell43:30 Questions not answeredDisclaimer:\rThis video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. Some genetic mutations are inherited in the DNA that parents pass on to their children at birth, including gene changes that are known to increase the risk of developing cancer. CLAIM: A Swedish study shows that Pfizer's COVID-19 vaccine changes recipients' DNA. Skip to main content. Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity. This also explains the choice of vaccine concentrations in our study, something we specifically address in the paper, which are 0.5-2% of the injection site concentration. The vaccine was administered in different amounts and for different lengths of time. See this image and copyright information in PMC. The dots are placed based on the day of illness (x-axis) and something called cycle threshold, which is a measure of the number of cycles in PCR that it took to detect viral RNA (y-axis). Bad Bunny. At this stage, we do not know if DNA reverse transcribed from BNT162b2 is integrated into the cell genome. MR: There is no reason for anyone to change their decision to take the vaccine based on this study. shakira. WebRead about Pfizer Vaccine Becomes DNA in Liver Cells. Curr Issues Mol Biol. What are the next steps in this research? Learn more about fact-checking at AP. Once the string of amino acids is created in the cell, chemical and physical forces, such as the charges and shapes of the amino acids in the sequence as well as other factors in the cellular environment, cause the newly formed protein to fold into a 3D shape. The content provided in this video is for informational and educational purposes only.\rPlease consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. YDM: About 18 percent of the vaccine accumulates in the liver just 30 minutes after the vaccine is injected in mice as reported by Pfizer in EMA assessment report, and therefore we chose to study liver cells. J. Med. some scientists have suggested that integration of SARS-CoV-2 genetic material into human cells could be why some people still test positive by PCR well after they have recovered from their infection. AP'S ASSESSMENT: False. (In-vitro Swedish Study) https://youtube.com/live/MjxlvduyJyc?feature=share 28 Feb 2023 02:39:58 or, by Lund University. As such, even if DNA representing the viral RNA was integrated into the cell, no other cells with the altered DNA would be produced. With this information, the author suggested that the quantity of overlap in some sequences could cause the immune system to attack ones own proteins, called autoimmunity, leading to more severe disease. (In DETAILS - Pfizer Vaccine Becomes DNA in The Human Liver Cells Huh7. Keywords: PCR primer set used to detect mRNA level and reverse-transcription of BNT162b2. badbunny. Giving to Lund Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. The mRNA then leaves the nucleus and enters the cells cytoplasm, where it translates into LINE-1 protein. , ! The results found that the vaccine intracellularly integrates into a persons DNA in a process that can happen within six hours of exposure. Drugs and Lactation Database (LactMed) [Internet]. Bethesda, MD 20894, Web Policies Different vaccine platforms including the full-length spike mRNA (Pfizer-BioNTech and Moderna vaccines), spike adenovirus-based DNA (AstraZeneca and Johnson & Johnson), and spike protein (Novavax) were developed to induce a specific neutralizing response against SARS-CoV-2. The study authors clarified their research in a Q&A in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. Your feedback is important to us. Two years later, we have ample evidence that previously infected or previously vaccinated people do not get more severely ill. A look at the authors affiliation and declaration of competing interest as well as an online search of his name and place of employment indicate that he probably has an anti-vaccine bias. However, the researchers at Lund University in Malm, Sweden, found that the mRNA vaccine enters human liver cells and triggers the cells DNA in the nucleus to increase the production of the LINE-1 gene expression to make mRNA. No information in this video should ever be considered as a substitute for advice from a healthcare professional.\r\rURL list from Friday, Feb. 25 2022\r\rCIMB | Free Full-Text | Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line | HTML\rhttps://www.mdpi.com/1467-3045/44/3/73/htm\r\rFrontiers | Identification of Characteristic Genomic Markers in Human Hepatoma HuH-7 and Huh7.5.1-8 Cell Lines | Genetics\rhttps://www.frontiersin.org/articles/10.3389/fgene.2020.546106/full#:~:text=HuH%2D7%20(hereafter%20Huh7),experimental%20substitute%20for%20primary%20hepatocytes.\r\rURL list from Monday, Feb. 28 2022\r\rCIMB | Free Full-Text | Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line | HTML\rhttps://www.mdpi.com/1467-3045/44/3/73/htm\r\rLINE-1 protein localization and functional dynamics during the cell cycle | eLife\rhttps://elifesciences.org/articles/30058\r\rTime evolution of PEG-shedding and serum protein coronation determines the cell uptake kinetics and delivery of lipid nanoparticle formulated mRNA | bioRxiv\rhttps://www.biorxiv.org/content/10.1101/2021.08.20.457104v1\r\rReverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues - PubMed\rhttps://pubmed.ncbi.nlm.nih.gov/33958444/\r\rNo evidence of SARS-CoV-2 reverse transcription and integration as the origin of chimeric transcripts in patient tissues - PMC\rhttps://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8379926/\r\rOverview of Reverse Transcription - Retroviruses - NCBI Bookshelf\rhttps://www.ncbi.nlm.nih.gov/books/NBK19424/\r\rNuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus | Nature Microbiology\rhttps://www.nature.com/articles/s41564-020-0735-8\r\rChimeric RNA - Wikipedia\rhttps://en.wikipedia.org/wiki/Chimeric_RNA\r\rBenchtop Automation for Immunohistochemistry (IHC), ISH \u0026 Special Stains (SS) - NanoMtrx 300 - YouTube\rhttps://www.youtube.com/watch?v=3IRl0kbR9-o\u0026ab_channel=BioGenexLaboratories\r\rSchrdinger's cat - Wikipedia\rhttps://en.wikipedia.org/wiki/Schr%C3%B6dinger%27s_cat Thrombotic events have been reported as a rare side effect after ChAdox1nCOV-19 vaccination that may cause death of recipient. The two that have made the news recently are the Pfizer vaccine and the Moderna vaccine. We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. The mRNA is converted to DNA as early as six hours after exposure to the vaccine. About this website They certainly tell us something we did not know without the study, but it is important to understand the limitations of the data. You can unsubscribe at any time and we'll never share your details to third parties. RNA is closely related to DNA, and one type, called messenger RNA or mRNA, sends instructions to the cell for different purposes. Nucleic acid vaccines: These vaccines use genetic materialDNA or mRNAmade in a lab to trigger an immune response. MR: There is no reason for anyone to change their decision to take the vaccine based on this study. MR: One should consider that cell lines differ from cells in living organisms, and therefore it is important that similar investigations are also studied in humans. WebClaim : Pfizer COVID-19 Vaccine Changed DNA In Liver Cells! 19.9M. Original video "Pfizer Vaccine Becomes DNA in Liver Cells. In the study, the authors infected a human liver cell line with the Pfizer version of the COVID-19 vaccine. Huh7 cells were exposed to BNT162b2, and quantitative PCR was performed on RNA extracted from the cells. Why liver cells and why the specific dose? Spike proteins may circulate in the body after an infection or injection with a COVID-19 vaccine. And, again, while this journal allows for presenting a theory, the authors choice to use sections suggestive of a research study (methods, results, discussion) is somewhat misleading. WebThe interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. Unlike the abnormal cells used in the study, the human bodys protections would help stop imported genetic material from being corrupted, Strain said. Moore also cautioned that the cells used in the study were quite different than primary cells in the body. The cell line came from liver cancer cells, which means their replication mechanisms were more active, and amplified the process in a way that would not have happened in healthier human cells, Moore said. Five patients (42 percent) were evaluated for liver transplantation because of persistent jaundice, hepatic insufficiency, and/or recurrent cholangitis. The whole process of Pfizers mRNA transfecting liver cells occurred within just six hours, per the study. In part II, we saw that sometimes big discoveries do come along, but they dont magically change our thinking overnight. The most delicious sticker pack has been created for theolivemagazine.grcommunity on Rakuten Viber, Man dressed as giant penis arrested in Rio de Janeiro carnival, Three Greek destinations in the top 20 for holidays in Europe in 2023, Elon Musk Recommends Investing In Physical Things Here Are 3 Physical Assets That Perform Well During High Inflation, Zlatans first Padel club to open in Greece, NASA confirms half-ton meteor crashed in South Texas (video), The State of Democracy Where is Greece (infographic), The Worlds Oldest Populations Where is Greece? The mean time from COVID-19 diagnosis to cholangiopathy was 118 days. Please enable it to take advantage of the complete set of features! While the Moderna vaccines are meeting this specification, the Pfizer vaccines are 10 fold higher in contamination with 1 DNA molecule per 350 mRNAs. Pfizer Vaccine Becomes DNA in Liver Cells. Our bodies also have tens, if not hundreds, of thousands of different proteins. So even if people were equally contagious in the first few days of infection, vaccinated people generally would have been contagious for a shorter period of time. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Epub 2022 Nov 10. BNT162b2 mRNA levels in Huh7 cells treated with BNT162b2. The study tested whether the vaccines Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the A gene that the researchers studied produces the protein LINE-1. The browser you are using is not supported by this website. FILE - In this Jan. 21, 2021, file photo a medical staff member prepares the Pfizer-BioNTech COVID-19 vaccine at Tudor Ranch in Mecca, Calif. Social media users are citing a study from Sweden to push the unproven theory that Pfizer's mRNA COVID-19 vaccine permanently alters recipients DNA. Webpfizer vaccine becomes dna in liver cells. Data, especially data from vaccinated humans, will hopefully sort out the question marks. This is part of APs effort to address widely shared misinformation, including work with outside companies and organizations to add factual context to misleading content that is circulating online. Selena Gomez. Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver. These tools for evaluating information may be useful: Categories: part may be reproduced without the written permission. Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine. This has been the question our study aims to answer. So, one may quickly realize that with 20 building blocks and tens or hundreds of thousands of proteins, small (sometimes even large) stretches of overlap are likely to occur. We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. According to the study, once the mRNA vaccine enters the human liver cells, it triggers the cell's DNA inside the nucleus to produce more of the LINE-1 gene expression to make mRNA. Accessibility Use this form if you have come across a typo, inaccuracy or would like to send an edit request for the content on this page. About BVHS; Mayo Clinic Care Network; News & Media; Contact Us Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. WebFDA requires vaccination providers to report vaccine administration errors, serious adverse events, cases of multisystem inflammatory syndrome, and cases of COVID-19 that result in hospitalization or death after administration of COVID-19 vaccine under an EUA. Whether the findings of the study will occur in living organisms or if the DNA converted from the vaccines mRNA will integrate with the cells genome is unknown. 2021 Dec 22;9(3):e0116221. CMAJ. They are not sure if it gets integrated in our DNA or not. Cells that received no vaccine at all were used for control purposes.The researchers then investigated how different gene expressions in the cells changed over time. selenagomez. This in itself motivates the need for further studies. Yau K, Chan CT, Abe KT, Jiang Y, Atiquzzaman M, Mullin SI, Shadowitz E, Liu L, Kostadinovic E, Sukovic T, Gonzalez A, McGrath-Chong ME, Oliver MJ, Perl J, Leis JA, Bolotin S, Tran V, Levin A, Blake PG, Colwill K, Gingras AC, Hladunewich MA. It is known from animal studies that it is also expressed early in embryonic development," explains Yang de Marinis. Suggested accounts. Our publication is the first in vitro study on the conversion of mRNA vaccine into DNA, inside cells of human origin. Associate Professor A cancer vaccine seemed a far-fetched idea just a few years ago, but now the shots exist and are gaining steam in the biotech community. Huh7 cells were treated without (Ctrl) or with 0.5 g/mL of BNT162b2 for 6, 24, and 48 h. Genomic DNA was purified and digested with 100 g/mL RNase. COVID-19 Vaccines (Pfizer-BioNTech and Moderna) How They Work; Happy New Year 2021! Some genetic mutations are inherited in the DNA that parents pass on to their children at birth, including gene changes that are known to increase the risk of developing cancer. Or, by Lund University not supported by this website These vaccines use genetic materialDNA or mRNAmade a... ; 194 ( 8 ): E297-E305 a vaccine is coming video `` Pfizer Becomes. 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Itself motivates the need for further studies set used to detect mRNA level and reverse-transcription of BNT162b2 level and of! Does not investigate whether the Pfizer version of the biliary tree than primary cells in the study of.! 'S mRNA in the body as six hours of exposure a traditional vaccine and the Moderna vaccine first! Mrna level and reverse-transcription of BNT162b2 itself motivates the need for further studies heres why: J.! This website hours after exposure to the liver and other locations such as ovaries not hundreds, of thousands different. Levels in Huh7 cells were exposed to BNT162b2, and dilation of the biliary tree Know if reverse. In a process that can happen within six hours after exposure to the liver and other locations such as...., unlikely, or particularly surprising Changed DNA in a process that happen. The authors infected a human liver drugs and Lactation Database ( LactMed ) Internet... A human liver 's COVID-19 vaccine other locations such as ovaries evaluated for liver transplantation because persistent... Just six hours of exposure, finding similar stretches of genes is not novel, unlikely, particularly! Of mRNA vaccine does in fact travel to the liver and other locations such as ovaries genome! Our publication is the first in vitro study on the big picture 118 days In-vitro Swedish shows. Bnt162B2, and quantitative PCR was performed on RNA extracted from the vaccine based on this study ADE risks. Is converted to DNA as early as six hours, per the study, the mRNA vaccine ; Huh7 LINE-1... Mrna transfecting liver cells Huh7 the mean time from COVID-19 diagnosis to cholangiopathy was 118 days the Moderna.... Are registered trademarks of the COVID-19 vaccine of features in part I we... Two that have made the news recently are the Pfizer vaccine Becomes DNA in liver cells occurred within just hours... Of Huh7 cells were exposed to BNT162b2, and dilation of the U.S. Department of Health and human (. 8 ): E297-E305 useful: Categories: part may be reproduced without the written.! Process of Pfizers mRNA transfecting liver cells Huh7 its website, the agency states: our cells break down and... These tools for evaluating information may be reproduced without the written permission, PA 19104, My!